Simulation of Oral Glucose Tolerance Tests and the Corresponding Isoglycemic Intravenous Glucose Infusion Studies for Calculation of the Incretin Effect

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Simulation of Oral Glucose Tolerance Tests and the Corresponding Isoglycemic Intravenous Glucose Infusion Studies for Calculation of the Incretin Effect

The incretin effect, which is a unique stimulus of insulin secretion in response to oral ingestion of nutrients, is calculated by the difference in insulin secretory responses from an oral glucose tolerance test (OGTT) and a corresponding isoglycemic intravenous glucose infusion (IIGI) study. The OGTT model of this study, which is individualized by fitting the glucose profiles during an OGTT, w...

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Sixty minutes' intravenous glucose infusion tests were carried out in normal subjects, borderline cases, and diabetics which were diagnosed by 50 g oral glucose tolerance test . Infusion was performed at the rate of 5 mg/kg/min . or 15 mg/kg/min. using 5% or 10% glucose. The difference in the insulin responses among thesegroups was rather marked in the case of 15 mg/kg/min. infusion of 10% gluc...

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ژورنال

عنوان ژورنال: Journal of Korean Medical Science

سال: 2014

ISSN: 1011-8934,1598-6357

DOI: 10.3346/jkms.2014.29.3.378